Endocrine Abstracts

Introduction: Hypogonadotropic hypogonadism(HH) is mandatory treated with testosterone (T). However, gonadotropin(hCG/FSH) administration might be the challenging optimal therapy.Case 1: Male, 23-y-old, hypophisectomy pp. adenoma hromophobum, one month later- FSH 1.5 U/L, LH 0.55 U/L. Primogonyl(hCG) test; testosteronemia: 0 day 0.069, 3 day 19.01 nmol/l. After 5 m in ejaculate no sperm. 5 m after introduction of hCG twice weekly 1,500 i.u. and FSH+LH 15...

The prevalence of osteoporosis among men is not well-documented. The aim of this cross-sectional study is to analyze results of DXA scans preformed in males in Clinical center of Vojvodina between years 2009 and 2016. Form the total of 2006 fist DXA scans performed in 7 years period there was 14.8% of males. DXA scan was indicated by the rheumatologists, internists and endocrinologists predominantly for suspected secondary causes of osteoporosis. We divided male subjects in gr...

Introduction: It is indisputable importance of vitamin D for the preserved integrity of the skeleton and bone metabolism.The aim of the study was to analyse bone turnover parameters in relation to the vitamin D status in women with postmenopausal osteoporosis.Materials and methods: This study included a total of 195 postmenopausal women with osteoporosis. Osteoporosis is diagnosed by DXA scan of the spine and hip. Bone turnover mar...

Introduction: Literature data suggests increased fracture risk in women with diabetes mellitus type 2 but the underlying mechanism is not fully understood.Aim of the study was to analyse bone turnover parameters in women with DM2 and in healthy women with osteoporosis in menopause.Materials and methods: There were 76 participants out of wich 36 women with DM2. Average diabetes duration was 14.48±10.51 years with mean HbA1c 7.8...

Introduction: Although diagnostics and therapy are much improved over the years, women with gestational diabetes still have more adverse course and outcome of pregnancy than healthy women. Their pregnancies are more often complicated with the different forms of maternal and fetal morbidity. Our study investigates all cause early neonatal morbidity (neonatal jaundice, neonatal hypoglycemia, fetal distress syndrome and other) and newborns maturity and vitality in the groups of d...

Introduction: Vertebral fragile fracture is risk factor for future vertebral and hip fractures.Aim: To establish prevalence of vertebral fractures using lateral DXA scan of thoracic and lumbar spine in women with postmenopausal osteoporosis.Method: Study comprised 73 women with postmenopausal osteoporosis diagnosed using spine and hip DXA. Vertebral fractures were verified by lateral DXA scan vertebral morphometry of thoracic and l...

Relation between thyroid hormones and bone metabolism markers in hyperthyroidism is well known. Earlier studies indicate possibility of bone metabolism acceleration during the excessive replacement therapy with L-thyroxine in hypothyroid patients especially in one with other risk factors for bone metabolism impairment. This study evaluated the effect of physiological L-thyroxine treatment on bone metabolism in patients with primary hypothyroidism....

Introduction: The coexistence of primary hyperparathyroidism with autoimmune diseases is described very rarely in the literature so far. There are only few cases of immune-mediated hyperparathyroidism, associated with anti-calcium- sensing receptor autoantibodies, frequently in context with other immune diseases. Spontaneous remission of primary hyperparathyroidism in anti-TNF therapy of psoriatic arthritis has also been described in one case. Prevalence of positive antithyroi...

Introduction: Bisphosphonates are commonly used in the treatment of osteoporosis. The aim was to determine the effect of bisphosphonate therapy for osteoporosis on bone mineral density (BMD) depending on the Dolga index.Materials and methods: The study included 36 postmenopausal women with osteoporosis. BMD was measured by DXA of the spine and hip before treatment and 2 years after starting bisphosphonate therapy. Parameters of bone turnover: osteocalcin...